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Objective:To evaluate the clinical efficacy of self-made Yangyin Yiqi Quxie Decoction combined with fire-needle pricking collaterals and bloodletting in the treatment of rosacea with excessive heat of lung and stomach syndrome.Methods:From February 2018 to February 2021, 120 patients with rosacea excessive heat of lung and stomach syndrome in our hospital who met the inclusion criteria were randomly divided into 2 groups by the two-color ball method, with 60 in each group. The control group was given conventional western medicine, fire-needle pricking collaterals and bloodletting therapy, while the study group was given self-made Yangyin Yiqi Quxie Decoction on the basis of the control group. Both groups were treated for 6 weeks. The clinical symptoms were scored before and after treatment, the levels of serum IL-6, IL-17 and IL-37 were detected by chemiluminescence method, the adverse reactions during treatment were recorded and the clinical efficacy was evaluated.Results:The total effective rate was 90.0% (54/60) in the study group and 70.0% (42/60) in the control group, and there was significant difference between the two groups ( χ2=7.50, P=0.006). After treatment, the levels of serum IL-6, IL-17 and IL-37 in the study group were significantly lower than those in the control group ( t values were 30.94, 9.73 and 14.84, respectively, all Ps<0.001), the scores of burning, pustules, pruritus, dryness, erythema, telangiectasia and the total scores in the study group were significantly lower than those in the control group ( t values were 5.68, 14.69, 10.35, 15.83, 13.44, 14.37 and 23.13, respectively, all Ps<0.001). There were no obvious adverse reactions in both groups during treatment. Conclusion:The self-made Yangyin Yiqi Quxie Decoction combined with fire-needle pricking collaterals and bloodletting can relieve the symptoms in patients with rosacea excessive heat of lung and stomach syndrome, reduce serum inflammatory cytokine levels, and improve clinical effects.
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Objective To explore the effect of different speed of bladder irrigation after transurethral resection of prostate.Methods 477 cases of benign prostatic hyperplasia,who received transurethral resection surgery were collected.According to the date of surgery,they were divided into observation group(in a single day,249 cases)and control group(double day,228 cases).The normal saline was used in the two groups,and the control group was washed with the conventional bladder irrigation,and the observation group was treated with the early rapid(no speed limit opening)and the routine velocity alternating flushing.The incidence of bladder spasm,the incidence of bladder spasm,the bleeding of bladder and the changes of heart rate and the mean arterial pressure of 24h were compared. Results Urine turned clear time,the total fluid,postoperative 5d red blood cell count of the observation group[(19.8 ± 8.3)h,(44.7 ±6.1)L,(25.8 ±11.3)months/μL]were significantly lower than the control group[(25.4 ±9.0)h, (52.3 ±7.4)L,(33.4 ±10.1)months/μL],the differences between the two groups were statistically significant(t =-6.270,-2.417,-10.459,all P 0.05).Conclusion The early rapid and conventional alternating washing method can improve the seizure of bladder spasm after prostatectomy,and reduce the bleeding of bladder.
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Objective To find out common allergens in Rizhao by investigating the allergens in patients with allergic rhinitis.Method The allergens in 686 patients with allergic rhinitis in Rizhao were detected by skin prick test.Results 509 of 686(74.20%)cases presented positive reaction,in which,the positive rate was 70.99%in inhalation group and 30.61%in food group,the most common inhalation allergen was pteronyssinus,then was dermatophagoides farinae,cockroaches;The most common food allergen was the jellyfish,then was peaches,peanuts.Conclusion The inhaled allergens were the main risk factors for allergic rhinitis,in which,mites was the most common allergens.
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Objective To test the content of menthol in Chuanbei Pipa Syrup(CPS)by GC, and to evaluate its quality. Meth-ods The content of menthol in CPS was determined by capillary gas chromatography. DB-WAX capillary column (30 m ×0. 319 mm × 0. 50μm) was used with nitrogen as carrier gas. The precolumn pressure was 500 kPa and the column temperature was at 110 ℃ with split ratio of 25 : 1. The temperature was set at 250℃ for sample injection and for the detector. Results The content of menthol in CPS produced by Henan Pharmaceutical Co. , Ltd. , Zhengzhou Pharmaceutical Co. , Ltd. and Yunan Pharmaceutical Co. , Ltd. was 0. 154 mg/mL, 0. 203 mg/mL and 0. 109 mg/mL, respectively. Of them, the men-thol content in CPS produced by Zhengzhou Pharmaceutical Co. , Ltd. met the requirements of Pharmacopoeia(2005 edition), and that of the other two species was slightly lower. Conclusion The methods are convenient, reliable and accurate for the de-termination of menthol content in Chuanbei Pipa Syrup.
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A new nested-polymerase chain reaction (nested-PCR) assay was developed to detect human parvovirus B19 DNA corresponding to the nonstructural protein in clinical specimens in a routine diagnostic laboratory. The sensitivity of this highly specific assay was up to 0.005 fg of B19 DNA. Parvovirus B19 was identified in sera of 20 pregnant women with abnormal pregnant outcome. Among these 20 cases, intrauterine parvovirus infection did exist in 7 pregnant women because parvovirus B19 DNA was detected in the pregnant tissues of them such as placenta tissues, chorionic villi, amniotic fluid, fetal spleen, liver and abdominal fluids.
Subject(s)
DNA, Viral/analysis , Parvoviridae Infections/virology , Parvovirus B19, Human/genetics , Parvovirus B19, Human/isolation & purification , Placenta/virology , Pregnancy Complications, Infectious/diagnosis , Pregnancy Complications, Infectious/virology , Viral Nonstructural Proteins/analysisABSTRACT
A new nested-polymerase chain reaction (nested-PCR) assay was developed to detect human parvovirus B19 DNA corresponding to the nonstructural protein in clinical specimens in a routine diagnostic laboratory. The sensitivity of this highly specific assay was up to 0. 005 fg of B19 DNA. Parvovirus B19 was identified in sera of 20 pregnant women with abnormal pregnant outcome. Among these 20 cases, intrauterine parvovirus infection did exist in 7 pregnant women because parvovirus B19 DNA was detected in the pregnant tissues of them such as placenta tissues,chorionic villi, amniotic fluid, fetal spleen, liver and abdominal fluids.
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To explore the pathogenic factors and diagnosi s of cerebral palsy (CP) in children, perinatal history, clinical evaluation, im aging and electrophysiological data and parents' attitude for rehabilitation of CP were analyzed and investigated in 50 children with CP retrospectively. The re sults showed that prem ature birth, low birth weight and perinatal asphyxia were the most pathogenic fa ctors induced CP. The common CP types was spastic paralysis, in particular quadr iparesis. Abnormal CT and MRI findings were detected in 68% of CP children. It w as noticed that 44% of CP children were with speech and language disorder, 32% w i th mental retardation, 18% with hearing impairment, 16% with visual impairment a nd 16% with epilepsy. There were 86% parents to accept with physiotherapy on the ir CP children, 68% with acupuncture therapy, 46% with occupational therapy and 100% with speech therapy, respectively. It is suggested that multi-subjec t cooperation will be necessary for the follow-up study of the high- risk infants. The realization of the related-speciality knowledge a nd the enhancement of rehabilitational conception will be helpful for the early diagnosis and intervention of CP patients. The popularization of rehabilitationa l conception will be also important in the parents with CP children.
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Objective To evaluate the relationship between maternal antepartum fever and early-onset neonatal bacterial sepsis.Methods A retrospective multi-centred clinical study of 404 neonates including 103 new borns with maternal antepartum fever and 311 neonates without was conducted.Results The frequency of early-onset neonatal bacterial sepsis was significantly higher in neonate with maternal antepartum fever than those without(4.9% vs 0.3%,P=0.001).Both maternal antepartum temperature ≥39℃ and maternal postpartum fever lasting several days was higher suggested the possibility of neonatal sepsis.Conclusions The neonates born with high risk factor of early-onset neonate bacterial sepsis require comprehensive lab evaluation including blood culture and uterine culture,clinical observation and aggressive treatment to decrease the mortality.